Composition
Each ml contains Cyclosporine 100mg.
Also contains inactive ingredients: Ethanol, Propylene glycol, starch oil and Hydrogenated Castor oil.

Indications and Dosage
Severe acute ulcerative colitis refractory to corticosteroid treatment
• Adult: Initially 2.5 mg/kg daily in 2 divided doses, increased if necessary up to 4 mg/kg daily after 6
weeks, if dose increases are necessary they should be made gradually, discontinue if response
insufficient after 3 months, dose adjusted according to response for
maintenance and treatment reviewed after 6 months (continue only if benefits outweigh risks)
Short-term treatment of severe atopic dermatitis where conventional therapy ineffective or
inappropriate (administered on expert advice)
• Adult: Initially 1.25 mg/kg twice daily (max. per dose 2.5 mg/kg twice daily) usual maximum duration
of 8 weeks but may be used for longer under specialist supervision, if good initial response not
achieved within 2 weeks, increase dose rapidly up to maximum
Short-term treatment of very severe atopic dermatitis where conventional therapy ineffective or
inappropriate (administered on expert advice)
• Adult: 2.5 mg/kg twice daily usual maximum duration of 8 weeks but may be used for longer under
specialist supervision
Severe psoriasis where conventional therapy ineffective or inappropriate (administered on expert
advice)
• Adult: Initially 1.25 mg/kg twice daily (max. per dose 2.5 mg/kg twice daily), increased gradually to
maximum if no improvement within 1 month, initial dose of 2.5 mg/kg twice daily justified if condition
requires rapid improvement; discontinue if inadequate response after 3 months at the optimum dose;
max. duration of treatment usually 1 year unless other
treatments cannot be used
Organ transplantation (used alone)
• Adult: 10–15 mg/kg, to be administered 4–12 hours before transplantation, followed by 10–15
mg/kg daily for 1–2 weeks postoperatively, then maintenance 2–6 mg/kg daily, reduce dose gradually
to maintenance. Dose should be adjusted according to blood-ciclosporin concentration and renal
function; dose is lower if given concomitantly with other immunosuppressant therapy (e.g.
corticosteroids); if necessary one-third corresponding oral dose can be given by intravenous infusion
over 2–6 hours Bone-marrow transplantation
Prevention and treatment of graft-versus-host disease
• Adult: 5 mg/kg daily in 2 divided doses, for maintenance reduce to lowest effective dose according
to proteinuria and serum creatinine measurements; discontinue after 3 months if no improvement in
glomerulonephritis or glomerulosclerosis (after 6 months in membranous glomerulonephritis)